Important Disorders and Treatments Associated With Eosinophilia
Cause or Associated Disorder | Examples |
|---|---|
Allergic or atopic disorders | Allergic bronchopulmonary aspergillosis Drug reactions (eg, to antibiotics or NSAIDs) Episodic angioedema with eosinophilia Milk-protein allergy Occupational lung disease |
Systemic rheumatic diseases, vasculitic or granulomatous disorders (especially those involving the lungs) | Eosinophilic granulomatosis with polyangiitis Idiopathic eosinophilic synovitis Kimura disease (angiolymphoid hyperplasia) Post myocardial infarction syndrome (Dressler syndrome) Progressive systemic sclerosis (scleroderma) |
Endocrine disorders | Adrenal hypofunction |
Immune disorders (often with eczema) | Congenital immunodeficiency syndrome (eg, IgA deficiency, hyper-IgE syndrome, Wiskott-Aldrich syndrome) |
Myeloproliferative disorders | Acute or chronic eosinophilic leukemia Acute lymphoblastic leukemia (certain types) |
Nonparasitic infections | Chlamydial pneumonia of infancy Coccidioidomycosis (acute) Infectious lymphocytosis Mycobacterial disease |
Parasitic infections (especially due to tissue-invasive metazoans) | Cysticercosis (caused by Taenia solium) Pneumocystis jirovecii infection |
Skin disorders | |
Syndromes of pulmonary infiltration with eosinophilia | Allergic bronchopulmonary aspergillosis Chronic eosinophilic pneumonia Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) Tropical pulmonary eosinophilia |
Tumors | Angioimmunoblastic T-cell lymphoma (previously known as angioimmunoblastic lymphadenopathy with dysproteinemia or AILD) in association with systemic symptoms and autoimmune hemolytic anemia Carcinomas and sarcomas of the lung, pancreas, colon, cervix, or ovary |
Miscellaneous | Familial eosinophilia Peritoneal dialysis Radiation therapy |
NSAID = nonsteroidal anti-inflammatory drug. | |