Serum Complement Profiles in Membranoproliferative Glomerulonephritis

Classification Based on Immunofluorescence Microscopy

Complement Profile

Immunoglobulin/immune complex–mediated MPGN

Classic complement pathway activated

C3: Normal or mildly decreased

C4: Decreased

Complement-mediated MPGN

Alternate complement pathway activated

C3: Decreased

C4: Normal

MPGN without immunoglobulin or complement deposition

C3: Normal

C4: Normal