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Oral Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction

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Medication	Onset of Action	Comments
AvanafilAvanafil	30 minutes	Can be taken 15 minutes before intercourse Fatty food reduces absorption
SildenafilSildenafil	60 minutes	Duration of action: ≈ 4 hours Fatty food reduces absorption
TadalafilTadalafil	60 minutes	Duration of action: 24‒36 hours Low-dose tadalafil can be taken as a daily medication to provide baseline improvement in erectile functionLow-dose tadalafil can be taken as a daily medication to provide baseline improvement in erectile function Low-dose daily tadalafil is also used to treat BPH-related urinary symptomsLow-dose daily tadalafil is also used to treat BPH-related urinary symptoms Can be taken with fatty food
VardenafilVardenafil	60 minutes	Duration of action: ≈ 4 hours Fatty food reduces absorption