Oral Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction

Medication

Onset of Action

Comments

Avanafil

30 minutes

Can be taken 15 minutes before intercourse

Fatty food reduces absorption

Sildenafil

60 minutes

Duration of action: 4 hours

Fatty food reduces absorption

Tadalafil

60 minutes

Duration of action: 24‒36 hours

Low-dose tadalafil can be taken as a daily medication to provide baseline improvement in erectile function

Low-dose daily tadalafil is also used to treat BPH-related urinary symptoms

Can be taken with fatty food

Vardenafil

60 minutes

Duration of action: 4 hours

Fatty food reduces absorption

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