Some Antibiotic Regimens for Endocarditis in the United States*
Type | Medication And Dosage for Adults | Medication and Dosage for Adults Allergic to Penicillin |
|---|---|---|
≤ 0.1 mcg/mL) | For NVE For PVE | or |
> 0.1 mcg/mL) | ||
Enterococci | or or | |
or or | ||
or | — | |
HACEK microorganisms§ | or or | |
Noncoliform bacilli | — | |
* Antimicrobial sensitivity changes over time, and there are site-specific differences in antimicrobial susceptibility. Advice from a consultant familiar with these patterns is imperative. | ||
† Based on ideal rather than actual weight in patients with obesity. | ||
> 2 g/24 hours are administered. | ||
§ HACEK microorganisms: Haemophilus parainfluenzae, H. aphrophilus, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae. | ||
MIC = minimum inhibitory concentration; NVE = native valve endocarditis; PVE = prosthetic valve endocarditis. | ||
Adapted from Baddour LM, Wilson WR, Bayer AS, et al: Infective endocarditis in adults: Diagnosis, antimicrobial therapy, and management of complications; A scientific statement for healthcare professionals from the American Heart Association. Circulation 132 (15):1435–1486, 2015. doi: 10.1161/CIR.0000000000000296 | ||