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Some Serious Adverse Drug Reactions

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Adverse Drug Reaction	Types of Drugs	Examples
Anemia (resulting from decreased production or increased destruction of red blood cells)	Certain antibiotics	Chloramphenicol
	Medications used to treat malaria or tuberculosis in people with G6PD enzyme deficiency	Chloroquine Isoniazid Primaquine
Angioedema (swelling of the lips, tongue, and throat causing difficulty breathing)	ACE inhibitors	Captopril Enalapril Lisinopril
Bone fractures	Proton pump inhibitors	Esomeprazole Lansoprazole Omeprazole
Blood clots	Birth control medications (all forms including patches and pills)	Drospirenone/ethinyl estradiol Norelgestromin/ethinyl estradiol
Confusion and drowsiness	Sedatives, including many antihistamines	Diphenhydramine
Confusion and drowsiness	Antidepressants (especially in older people)	Amitriptyline Imipramine
Decreased production of white blood cells, with increased risk of infection	Certain antipsychotic drugs	Clozapine
	Chemotherapy drugs	Cyclophosphamide Mercaptopurine Methotrexate Vinblastine
	Some medications used to treat thyroid disorders	Propylthiouracil
Kidney damage	NSAIDs (repeated use of excessive doses)	Ibuprofen Naproxen
	Aminoglycoside antibiotics	Gentamicin Tobramycin
	Some chemotherapy drugs	Cisplatin Methotrexate
	Antifungals	Amphotericin B
	Some other antibiotics	Tetracycline (outdated) Vancomycin
Liver damage	Some analgesics	Acetaminophen (use of excessive doses)
	Some medications used to treat tuberculosis	Isoniazid
	Iron supplements (in excessive amounts)	Ferrous sulfate, ferrous fumarate
	Antidepressants	Duloxetine
	Antibiotics	Tetracycline
Muscle tissue destruction (rhabdomyolysis)	Statins	Atorvastatin Simvastatin
Stomach or intestinal ulcers (with or without bleeding)	NSAIDs	Aspirin Ibuprofen Naproxen
	Anticoagulants	Heparin Warfarin
	Bisphosphonates	Alendronate Risedronate
Toxic epidermal necrolysis	Some antibiotics	Penicillins Quinolones Sulfonamides
Toxic epidermal necrolysis	Anticonvulsants	Phenytoin Valproic acid
Ventricular tachycardia	Antiarrhythmics	Amiodarone Procainamide Sotalol
Ventricular tachycardia	Antipsychotics	Chlorpromazine Haloperidol Lithium
ACE = angiotensin-converting enzyme; G6PD = glucose-6-phosphate dehydrogenase; NSAIDs = nonsteroidal anti-inflammatory drugs.