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Juvenile xanthogranuloma is a dendritic cell-related histiocytic syndrome that usually affects only the skin, causing single or multiple lesions, which can resolve spontaneously.
Systemic involvement can occur, causing visceral organ lesions, involving the liver, lungs, and/or bone marrow.
Juvenile xanthogranuloma is rarely associated with neurofibromatosis and/or juvenile myelomonocytic leukemia
Langerhans cell histiocytosis. Mitogen-activated protein kinase (MAPK) pathway mutations have been identified, so targeted therapy can also be used.
Juvenile Xanthogranuloma
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