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Merck Manual
Professional Version
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Professional
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Hepatic and Biliary Disorders
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Approach to the Patient With Liver Disease
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Approach to the Patient With Liver Disease
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Liver Structure and Function
Overview of liver structure
Overview of bilirubin metabolism
Pathophysiology
Evaluation of the Patient With a Liver Disorder
History
Physical examination
Testing
The Asymptomatic Patient With Abnormal Liver Test Results
Aminotransferases
Alkaline phosphatase
Acute Liver Failure
Etiology
Pathophysiology
Symptoms and Signs
Symptoms and signs references
Diagnosis
Diagnosis reference
Treatment
Treatment references
Prognosis
Key Points
Ascites
Etiology
Pathophysiology
Symptoms and Signs
Diagnosis
Treatment
Treatment reference
Key Points
Inborn Metabolic Disorders Causing Hyperbilirubinemia
Crigler-Najjar Syndrome
Dubin-Johnson Syndrome and Rotor Syndrome
Dubin-Johnson syndrome
Rotor syndrome
Gilbert Syndrome
Primary Shunt Hyperbilirubinemia
Jaundice
Pathophysiology
Mechanisms of hyperbilirubinemia
Consequences
Etiology
Evaluation
History
Physical examination
Red flags
Interpretation of findings
Testing
Treatment
Geriatrics Essentials: Jaundice
Key Points
Metabolic Dysfunction–Associated Liver Disease (MASLD)
Pathophysiology
Symptoms and Signs
Diagnosis
Diagnosis references
Treatment
Prognosis
Prognosis references
Key Points
Portal Hypertension
Etiology
Pathophysiology
Symptoms and Signs
Diagnosis
Treatment
Treatment reference
Prognosis
Key Points
Portosystemic Encephalopathy
Etiology
Precipitants
Pathophysiology
Symptoms and Signs
Diagnosis
Treatment
Prognosis
Key Points
More Information
Postoperative Liver Dysfunction
Postoperative jaundice
Postoperative hepatitis
Postoperative cholestasis
Spontaneous Bacterial Peritonitis (SBP)
Symptoms and Signs
Diagnosis
Treatment
Systemic Abnormalities in Liver Disease
Circulatory Abnormalities
Endocrine Abnormalities
Hematologic Abnormalities
Renal and Electrolyte Abnormalities
Hepatorenal syndrome
Pulmonary Abnormalities