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Antibiotic Treatment of Staphylococcal Infections in Adults

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Infection	Antibiotics
Community-acquired cutaneous infections (non-MRSA)	Dicloxacillin or cephalexinDicloxacillin or cephalexin
Penicillin-allergic patients	ErythromycinErythromycin Clarithromycin Clarithromycin Azithromycin Azithromycin Clindamycin Clindamycin
Community-acquired cutaneous infections likely to be due to MRSA	Sulfamethoxazole/trimethoprimSulfamethoxazole/trimethoprim Clindamycin Clindamycin Linezolid Linezolid Tedizolid Tedizolid Delafloxacin Delafloxacin Omadacycline Omadacycline
Sulfa-allergic patients	Clindamycin Clindamycin Linezolid Linezolid TedizolidTedizolid Doxycycline Doxycycline Delafloxacin Delafloxacin Omadacycline Omadacycline
Serious infections unlikely to be due to MRSA	Nafcillin or oxacillin Nafcillin or oxacillin Cefazolin Cefazolin
Penicillin-allergic patients	Clindamycin Clindamycin VancomycinVancomycin
Serious infection highly likely to be due to MRSA	Vancomycin Vancomycin LinezolidLinezolid DaptomycinDaptomycin Ceftobiprole (not available in the United States) Ceftobiprole (not available in the United States) Ceftaroline Ceftaroline Delafloxacin Delafloxacin Omadacycline 2Omadacycline 2
Documented MRSA	By reported sensitivities
Vancomycin-resistant staphylococciVancomycin-resistant staphylococci	LinezolidLinezolid Quinupristin/dalfopristin Daptomycin Daptomycin Oritavancin Oritavancin Ceftobiprole (not available in the United States) Ceftobiprole (not available in the United States) Ceftaroline Ceftaroline
* No clinical data are available, but listed antibiotics appear to be active in vitro.
MRSA = methicillin-resistant Staphylococcus aureus.