Common Patterns of Laboratory Test Abnormalities

Pattern

Aminotransferase Elevations

Alkaline Phosphatase Elevations

Prolongation of Prothrombin Time (PT)

Acute necrosis or injury

Marked

Often present but may be mild

Prolonged if hepatic function is severely impaired

Chronic hepatocellular disease

Mild to moderate

Often present but may be mild

Prolonged if hepatic function is severely impaired

Cholestasis

Often present but may be mild

Marked

Prolonged if chronic steatorrhea causes vitamin K malabsorption

Can be corrected with parenteral (subcutaneous or intravenous) vitamin K

Infiltration

Mild

Mild to moderate

Not usually prolonged