Confirmatory Serum Testing for Secondary Adrenal Insufficiency

Test

Result

ACTH

Low (< 5 pg/mL [1.10 pmol/L])

Cortisol

Low (< 5 mcg/dL [138 nmol/L])

ACTH stimulation test

Normal or subnormal

Prolonged (24-hour) ACTH stimulation test

Cortisol should continue to rise for 24 hours

ACTH = adrenocorticotropic hormone.