Contraindications to Fibrinolytic Therapy

Absolute contraindications

Aortic dissection

Previous hemorrhagic stroke (at any time)

Previous ischemic stroke within 1 year

Active internal bleeding (not menses)

Intracranial tumor

Pericarditis

Relative contraindications

Blood pressure > 180/110 mm Hg after initial antihypertensive therapy

Trauma or major surgery within 4 weeks

Active peptic ulcer

Pregnancy

Bleeding diathesis

Noncompressible vascular puncture

Current anticoagulation (INR > 2)