Dosing of Oral First-Line Anti-TB Drugs*

Drug

Adults or Children

Daily†

Once/Week

2 Times/Week

3 Times/Week

Adults (maximum)

5 mg/kg (300 mg)

15 mg/kg (900 mg)

15 mg/kg (900 mg)

15 mg/kg (900 mg)

Children (maximum)

10–20 mg/kg (300 mg)

N/A

20–40 mg/kg (900 mg)

N/A

Adults (maximum)

10 mg/kg (600 mg)

N/A

10 mg/kg (600 mg)

10 mg/kg (600 mg)

Children (maximum)

10–20 mg/kg (600 mg)

N/A

10–20 mg/kg (600 mg)

N/A

Adults (maximum)

5 mg/kg (300 mg)

N/A

5 mg/kg (300 mg)

5 mg/kg (300 mg)

Children

10–20 mg/kg (300 mg)

N/A

10–20 mg/kg (300 mg)

10–20 mg/kg (600 mg)

Adults

N/A

10 mg/kg (600 mg)

N/A

N/A

Children

N/A

N/A

N/A

N/A

Adults (whole tablets):

40–55 kg

1 g

N/A

2 g

1.5 g

56–75 kg

1.5 g

N/A

3 g

2.5 g

76 kg§

2 g

N/A

4 g

3 g

Children (maximum)

15–30 mg/kg (2 g)

N/A

50 mg/kg (2 g)

N/A

Adults (whole tablets):

40–55 kg

800 mg

N/A

2000 mg

1200 mg

56–75 kg

1200 mg

N/A

2800 mg

2000 mg

76 kg§

1600 mg

N/A

4000 mg

2400 mg

Children (maximum)

15–20 mg/kg (1 g)

N/A

50 mg/kg (2.5 g)

N/A

≥ 12 years of age

400 mg

N/A

N/A

N/A

* Specific regimens are discussed in text.

† Daily is considered either 5 or 7 days/week. All dosing < 7 days/week must be given as directly observed therapy.

‡ Continuation phase only.

§ Maximum dose.

N/A = not applicable.

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