Drugs for Resuscitation*

Drug†

Adult Dose

Pediatric Dose

Comments

6 mg initially, then 12 mg × 2 if needed

0.1 mg/kg initially, then 0.2 mg/kg × 2

Rapid IV push is followed by flush (maximum single dose 12 mg).

For VF/pulseless VT: 300 mg IV push over 2 minutes

If persistent/pulseless VT, may give additional 150 mg

For VF/pulseless VT: 5 mg/kg IV push

If persistent VF/pulseless VT, may repeat up to 3 total doses

For perfusing VT:

  • Loading dose: 150 mg IV push over 10 minutes, followed by

  • Infusion (drip): 1 mg/minute × 6 hours, then 0.5 mg/minute × 24 hours

For perfusing VT: 5 mg/kg over 20–60 minutes, may repeat twice to a maximum of 15 mg/kg/day

1 mg, repeat every 3–5 minutes to effect or total dose of 3 mg, minimum dose 0.5 mg

0.02 mg/kg, repeat once in 3–5 minutes if needed, minimum dose 0.1 mg

1 g

20 mg/kg

10% solution contains 100 mg/mL.

Calcium gluceptate‡

0.66 g

N/A

22% solution contains 220 mg/mL.

3 g

30 mg/kg

10% solution contains 100 mg/mL.

2–5 mcg/kg/minute—increasing as needed to maximum 20 mcg/kg/min

Same as adult dose

500 mg in 250 mL 5% D/W gives 2000 mcg/mL.

2–5 mcg/kg/minute—increasing as needed to maximum 20 mcg/kg/min

Same as adult dose

400 mg in 250 mL 5% D/W gives 1600 mcg/mL.

Bolus: 1 mg

Infusion: 2–10 mcg/minute

Bolus: 0.01 mg/kg

Infusion: 0.1–1.0 mcg/kg/minute

1:10,000 (0.1 mg/mL) concentration

Repeat every 3–5 minutes as needed.

8 mg in 250 mL 5% D/W gives 32 mcg/mL.

Glucose

25 g 50% D/W

0.5–1 g/kg

Avoid high concentrations in infants and young children. Recommend using 10% D/W for infants and 10% or 25% for children

10% D/W: Give 5–10 mL/kg.

25% D/W: Give 2–4 mL/kg.

For older children, use a large vein.

1–1.5 mg/kg; repeat every 5–10 minutes to a maximum of 3 mg/kg

Loading dose: 1 mg/kg

Infusion: 20–50 mcg/kg/minute

Magnesium sulfate

1–2 g

25–50 mg/kg to a maximum of 2 g

Give over 2–5 minutes.

2 mg intranasal or 0.4 mg IM

0.1 mg/kg if patients are < 20 kg or < 5 years

Repeat as needed.

Infusion: 2–16 mcg/minute

Infusion: Starting with 0.05–0.1 mcg/kg/minute (maximum dose 2 mcg/kg/minute)

8 mg in 250 mL 5% D/W gives 32 mcg/mL.

30 mg/minute to effect or a maximum of 17 mg/kg

15 mg/kg over 30–60 minutes

50 mEq

1 mEq/kg

Infuse slowly and only when ventilation is adequate.

4.2% contains 0.5 mEq/mL; 8.4% contains 1 mEq/mL.

* For indications and use, see text.

† IV or intraosseous.

‡ Rarely used.

D/W == supraventricular tachycardia;VF = ventricular fibrillation; VT = ventricular tachycardia.