Genetic Testing for Huntington Disease

Number of CAG Repeats

Interpretation

≤ 26

Normal

27–35

Normal but unstable (increased risk that children will have Huntington disease)

36–39

Abnormal with variable penetrance; unstable (in some studies, most patients had symptoms and signs)

≥ 40

Abnormal with complete penetrance and anticipation (the greater the number of repeats, the earlier the onset of symptoms)

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