IV Fibrinolytic Therapies

Medication

Circulating half-life (minutes)

Concurrent heparin

Allergic reactions

Anistreplase

100

No

Yes

6

Yes

Rare

13–16

Yes

Rare

Streptokinase (not available in the United States)

20

No

Yes

Initial half-life of 20–24 minutes; terminal phase half-life of 90–130 minutes

Yes

Rare