Regimens for Treatment of Pelvic Inflammatory Disease*

Treatment

Recommended Regimens

Alternative Regimens

Parenteral†

Regimen A:

PLUS

PLUS

Regimen B:

OR

PLUS

Regimen C:

PLUS

Regimen D:

PLUS

Oral or IM†

Regimen A:

PLUS

WITH

Regimen B:

PLUS

WITH

Regimen C:

PLUS

WITH

Regimen D§:

OR

WITH

Regimen E:

WITH OR WITHOUT

* Recommendations are from the Centers for Disease Control and Prevention. Workowski KA, Bachmann LH, Chan PA, et al: Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep 70(4):1-187, 2021 doi:10.15585/mmwr.rr7004a1

† Intramuscular or oral therapy can be considered for mild to moderate acute PID because the clinical outcomes with intramuscular/oral and parenteral therapy are similar. If patients do not respond to oral therapy within 72 hours, they should be reevaluated to confirm the diagnosis, and intravenous therapy should be given.

§ This regimen may be considered if the patient has a cephalosporin allergy, if community prevalence and individual risk of gonorrhea are low, and if follow-up is likely. Tests for gonorrhea must be done before therapy is started, and the following management is recommended:

  • Positive culture for gonorrhea: Treatment based on results of antimicrobial susceptibility

  • Identification of quinolone-resistant Neisseria gonorrhoeae or antimicrobial susceptibility that cannot be assessed: Consultation with an infectious disease specialist.