Revised International Staging System for Multiple Myeloma
Stage | Criteria |
|---|---|
I | Beta-2 microglobulin < 3.5 mcg/mL (< 297 nmol/L) and Serum albumin ≥ 3.5 g/dL (≥ 35 g/L) Normal LDH Standard-risk cytogenetic abnormalities by FISH* |
II | Not stage I or III |
III | Beta-2 microglobulin ≥ 5.5 mcg/mL (≥ 466 nmol/L) and High-risk cytogenetic abnormalities by FISH† and/or high LDH |
* Standard-risk cytogenetic abnormalities include t(11;14), t(6;14), and trisomies. | |
† High-risk cytogenetic abnormalities consist of t(4;14), t(14;16), or 17p-. | |
FISH = fluorescent in situ hybridization; LDH = lactate dehydrogenase. | |
Data from Palumbo A, Avet-Loiseau H, Oliva S, et al. Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group. J Clin Oncol 2015;33(26):2863-2869. doi:10.1200/JCO.2015.61.2267 | |