Some Medications That Cause Syncope

Mechanism

Example

Bradyarrhythmia

Beta-blockers

Calcium channel blockers (not dihydropyridines)

Tachyarrhythmia

Any medication that prolongs repolarization* (eg, some antiarrhythmics, some antipsychotics, some antidepressants, some antihistamines, some fluoroquinolones)

Orthostatic hypotension

Most antihypertensives (rarely beta-blockers)

Antipsychotics (mainly phenothiazines)

Nitrates (with or without a phosphodiesterase inhibitor for erectile dysfunction)

Tricyclic antidepressants

For more information, see Porta L, Lee MG, Hsu WT, Hsu TC, Tsai TY, Lee CC: Fluoroquinolone use and serious arrhythmias: A nationwide case-crossover study. Resuscitation 139:262–268, 2019. doi:10.1016/j.resuscitation.2019.04.030

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