Syndromes Caused by Enteroviruses

Syndrome

Serotypes Most Often Implicated

Aseptic meningitis

Coxsackieviruses A2, 4, 7, 9, and others and B2–5

Poliovirus types 1–3

Echoviruses 4, 6, 7, 9, 11, 30, and others

Aseptic meningitis with rash

Coxsackieviruses A9 and B4

Echoviruses 4 and 16

Enterovirus A71

Conjunctivitis (hemorrhagic)

Enterovirus D70

Coxsackievirus A24

Epidemic pleurodynia (Bornholm disease)

Coxsackieviruses B1–6

Hand-foot-and-mouth disease

Coxsackieviruses A6, 9, 16, and others

Coxsackieviruses B2–5

Enterovirus A71

Herpangina

Coxsackieviruses A2, 4–6, 8, and 10

Probably coxsackieviruses B3 and others

Myopericarditis

Coxsackieviruses A4 and 16 and B1–5

Echoviruses 9 and human parechovirus 1

Poliomyelitis, acute flaccid myelitis

Polioviruses 1–3

Coxsackieviruses A7 and others

Echoviruses 4, 6, 9, and others

Enteroviruses A71, D68, D70

Rash

Coxsackieviruses A9 and B1, 3, 4, and 5 (also implicated: A4–6 and 16)

Echoviruses 9 and 16 (also implicated: 2, 4, 11, 14, 19, and 25)

Respiratory disease

Echoviruses 4, 8, 9, 11, 20, and others

Coxsackieviruses A21 and 24 and B1 and 3–5

Enterovirus D68