Ginger

A 2018 meta-analysis of 10 randomized controlled trials (918 subjects) suggested possible benefits of ginger in controlling the severity of postoperative nausea and vomiting (1). A meta-analysis of 13 studies (1174 subjects) reported ginger was significantly more effective than placebo in relieving pregnancy-related nausea but not vomiting. In this analysis, there was no significant difference between ginger and vitamin B6 in reducing nausea or vomiting (2). A 2019 systematic review and meta-analysis of ginger for chemotherapy-induced nausea and vomiting reported that ginger had no effect on chemotherapy-induced nausea and other related outcomes; however, the authors concluded that this might have been due to heterogeneity of the studies (3).

4). A 2015 meta-analysis of 5 studies (593 subjects) found that ginger was only moderately effective for osteoarthritis (5). However, for primary dysmenorrhea, randomized trials report that ginger powder may be beneficial (67).

Some Possible Dietary Supplement–Drug Interactions.)

1. 1. Toth B, Lantos T, Heygi P, et al: Ginger (Zingiber officinale): an alternative for the prevention of postoperative nausea and vomiting. A meta-analysis. Phytomedicine 50:8-18, 2018. doi: 10.1016/j.phymed.2018.09.007

2. 2. Hu Y, Amoah AN, Zhang H, et al: Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis. J Matern Fetal Neonatal Med 35(1):187-196, 2022. doi:10.1080/14767058.2020.1712714

3. 3. Crichton M, Marshall S, Marx W, et al: Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: a systematic review update and meta-analysis. J Acad Nutr Diet 119(12):2055-2068, 2019. doi: 10.1016/j.jand.2019.06.009 

4. 4. Terry R, Posadzki P, Watson LK, et al: The use of ginger (Zingiber officinale) for the treatment of pain: a systematic review of clinical trials. Pain Med 12(12):1808-1818, 2011. doi: 10.1111/j.1526-4637.2011.01261.x

5. 5. Bartels EM, Folmer VN, Bliddal H, et al: Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials. Osteoarthritis Cartilage 23(1):13-21, 2015. doi: 10.1016/j.joca.2014.09.024

6. 6. Daily JW, Zhang X, Kim DS, et al: Efficacy of ginger for alleviating the symptoms of primary dysmenorrhea: a systematic review and meta-analysis of randomized clinical trials. Pain Med 16(12):2243-55, 2015. doi: 10.1111/pme.12853

7. 7. Huang FY, Deng T, Meng LX, et al: Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Medicine (Baltimore) 98(13):e15054, 2019. doi: 10.1097/MD.0000000000015054

The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

1. National Institutes of Health (NIH), National Center for Complementary and Integrative Health: General information on the use of ginger as a dietary supplement