Drugs That Can Cause Serotonin Syndrome

Class

Drugs

Antidepressants: Monoamine oxidase inhibitors

Antidepressants: Serotonin-norepinephrine reuptake inhibitors

Antidepressants: Selective serotonin reuptake inhibitors (SSRIs)

Antidepressants: Tricyclic antidepressants

Central nervous system (CNS) stimulants

3,4-Methylenedioxyamphetamine (MDA)

3,4-Methylenedioxymethamphetamine (MDMA, or Ecstasy)

Sibutramine

Hallucinogens

Lysergic acid diethylamide (LSD)

5-Methoxy-diisopropyltryptamine

Herbs

Nutmeg

St John’s wort

Syrian rue

5-Hydroxytryptamine (5-HT1) agonists (triptans)

Opioids

Pentazocine

Pethidine

Others

5-Hydroxytryptophan

Valproate

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