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Drugs That Can Cause Serotonin Syndrome

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Class	Drugs
Antidepressants: Monoamine oxidase inhibitors	IsocarboxazidIsocarboxazid LinezolidLinezolid PhenelzinePhenelzine SelegilineSelegiline TranylcypromineTranylcypromine
Antidepressants: Serotonin-norepinephrine reuptake inhibitors	BupropionBupropion NefazodoneNefazodone TrazodoneTrazodone VenlafaxineVenlafaxine
Antidepressants: Selective serotonin reuptake inhibitors (SSRIs)	CitalopramCitalopram EscitalopramEscitalopram FluoxetineFluoxetine FluvoxamineFluvoxamine ParoxetineParoxetine SertralineSertraline
Antidepressants: Tricyclic antidepressants	AmitriptylineAmitriptyline AmoxapineAmoxapine DesipramineDesipramine DoxepinDoxepin ImipramineImipramine MaprotilineMaprotiline NortriptylineNortriptyline ProtriptylineProtriptyline TrimipramineTrimipramine
Central nervous system (CNS) stimulants	AmphetamineAmphetamine CocaineCocaine DiethylpropionDiethylpropion MethamphetamineMethamphetamine 3,4-Methylenedioxyamphetamine (MDA) 3,4-Methylenedioxymethamphetamine (MDMA, or Ecstasy) MethylphenidateMethylphenidate PhenterminePhentermine Sibutramine
Hallucinogens	Lysergic acid diethylamide (LSD) 5-Methoxy-diisopropyltryptamine
Herbs	Nutmeg Panax (Asian or American) ginsengPanax (Asian or American) ginseng St John’s wort Syrian rue
5-Hydroxytryptamine (5-HT1) agonists (triptans)	AlmotriptanAlmotriptan EletriptanEletriptan FrovatriptanFrovatriptan NaratriptanNaratriptan RizatriptanRizatriptan SumatriptanSumatriptan ZolmitriptanZolmitriptan
Opioids	BuprenorphineBuprenorphine FentanylFentanyl HydrocodoneHydrocodone MeperidineMeperidine OxycodoneOxycodone Pentazocine Pethidine TramadolTramadol
Others	BuspironeBuspirone ChlorpheniramineChlorpheniramine DextromethorphanDextromethorphan GranisetronGranisetron 5-Hydroxytryptophan LevodopaLevodopa LithiumLithium MetoclopramideMetoclopramide OlanzapineOlanzapine OndansetronOndansetron RisperidoneRisperidone RitonavirRitonavir TryptophanTryptophan Valproate