Anomalies cytogénétiques fréquentes dans la leucémie lymphoblastique aiguë
Anomalie cytogénétique | Incidence estimée (adultes) | Incidence estimée (enfants) | Pronostic |
|---|---|---|---|
t(9;22)/BCR-ABL1; (chromosome Philadelphie positif ou Ph+) | 25% | 5% | Mauvais |
Hyperdiploïdie (51–65 chromosomes dans les cellules leucémiques) | 2–11% | 25% | Favorable |
Hypodiploïdie (< 46 chromosomes dans les cellules leucémiques) | 5% | 5% | Mauvais |
t(12;21)/TEL-AML1 (ETV6-RUNX1) | < 3% | 20–25% | Favorable |
Données d'après Cytogenetic abnormalities in adult acute lymphoblastic leukemia: correlations with hematologic findings outcome. A Collaborative Study of the Group Français de Cytogénétique Hématologique [published correction appears in Blood 1996 Oct 1;88(7):2818]. Blood 1996;87(8):3135-3142, Fenaux P, Lai JL, Morel P, et al. Cytogenetics and their prognostic value in childhood and adult acute lymphoblastic leukemia (ALL) excluding L3. Hematol Oncol 1989;7(4):307-317. doi:10.1002/hon.2900070409, Pui CH, Crist WM, Look AT. Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Blood 1990;76(8):1449-1463, Bloomfield CD, Secker-Walker LM, Goldman AI, et al. Six-year follow-up of the clinical significance of karyotype in acute lymphoblastic leukemia. Cancer Genet Cytogenet 1989;40(2):171-185. doi:10.1016/0165-4608(89)90023-x, Walters R, Kantarjian HM, Keating MJ, et al. The importance of cytogenetic studies in adult acute lymphocytic leukemia. Am J Med 1990;89(5):579-587. doi:10.1016/0002-9343(90)90175-d, and Micallef-Eynaud PD, Eden OB, Grace E, Ellis PM. Cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Pediatr Hematol Oncol 1993;10(1):25-30. doi:10.3109/08880019309016524. | |||