Introduction to Symptoms of Musculoskeletal Disorders

ByAlexandra Villa-Forte, MD, MPH, Cleveland Clinic
Reviewed/Revised Apr 2025
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Musculoskeletal symptoms are very common and may arise from joints, bones, muscles, ligaments, tendons, or bursas (see Introduction to the Biology of the Musculoskeletal System).

Common symptoms of musculoskeletal disorders include the following:

Inflammation may cause pain, swelling, warmth, tenderness, impaired function, and sometimes redness of the overlying skin. Inflammation can result from many different musculoskeletal disorders, such as autoimmune disorders (for example, rheumatoid arthritis) and infections. When inflammation affects a joint, fluid may accumulate inside the joint, causing pain, swelling, and decreased range of motion.

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