In the United States, the overall incidence of cancer in children and adolescents has increased over time. In 2024, about 10,000 cases of cancer are expected to be diagnosed among children from birth to 14 years old, and about 5,300 cases of cancer are expected to be diagnosed among adolescents 15 to 19 years old. However, death rates have decreased from 1970 through 2020 by 70% in children and by 64% in adolescents.
Despite improvements in survival rates, cancer remains a major cause of death among children. In the United States, cancer is the second most common cause of death among children 1 to 14 years old (surpassed only by accidents) and is the fourth most common cause of death among adolescents 15 to 19 years old.
Some of the most common cancers that occur in children or adolescents (birth to age 14 years) can also occur in adults:
Leukemia, the most common childhood cancer (accounts for about 28% of childhood cancer cases)
Brain and other central nervous system tumors (25% of cases)
Lymphomas (12% of cases)
Osteosarcoma and Ewing sarcoma of bone (4% of cases)
Cancers that occur only in children (birth to age 14 years) are
In contrast to many cancers that affect adults, cancers that occur mainly in children tend to be much more curable. About 85% of children and adolescents with cancer survive at least 5 years. In the United States in 2020, it was estimated that there were about 500,000 adult survivors of childhood cancer (that is, they are adults who were first diagnosed with cancer before 20 years of age).
Complications of Cancer Treatment
Similar to cancer care in adults, doctors use a combination of treatments, including surgery, chemotherapy, stem cell transplantation, and radiation therapy, to treat children who have cancer. Immunotherapy (a newer type of treatment that uses the immune system to attack the cancer) and targeted therapy (medications that target specific gene mutations in cancer cells and destroy them) are being studied and are being used more often to treat cancer in children. Because children are still growing, these treatments, mainly chemotherapy and radiation therapy, may cause side effects that typically do not occur in adults. For example, in children, an arm or a leg treated with radiation may not grow to full size, or, if the brain is treated with radiation, cognitive development may not be normal. (See also Cancer Treatment Principles.)
Children who survive cancer have more years to develop long-term consequences of chemotherapy, surgery, and radiation therapy, which may include
Infertility
Poor growth
Delayed or no puberty
Damage to the heart and other organs
Development of second cancers (which occur in 3 to 12% of children who survive cancer)
Psychological and social problems
Developmental or neurologic problems or both
Because such severe consequences are possible and treatment is complex, children with cancer are best treated in centers where experts have experience treating childhood cancers.
The risk of having a second cancer depends on the type of first cancer. The risk also depends on whether radiation therapy was used to treat the first cancer or what type of chemotherapy was used.
Care Team for Cancer Treatment
The impact of being diagnosed with cancer and the intensity of the treatment can be overwhelming to the child and family. Maintaining a sense of normalcy for the child may be difficult, especially because the child may have to be hospitalized frequently and go to a doctor’s office or outpatient center for treatment of the cancer. It is common for parents to feel an overwhelming sense of stress as they struggle to continue to work, be attentive to siblings, and still attend to the many needs of their child who has cancer (see Chronic Health Problems in Children). The situation is even more difficult when the child is being treated at a specialty center far from home.
Did You Know...
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Children and parents need a pediatric treatment team to help manage care. Pediatric doctors are doctors who specialize in the care and treatment of babies, children, and adolescents. The team should generally include the following:
Pediatric cancer specialists (pediatric oncologist and radiation oncologist)
Pediatric oncology nurse, a registered nurse who cares for and educates children who have cancer and their families
Other needed specialists, such as a pediatric surgeon with expertise removing or biopsying childhood cancers, a pediatric radiologist with expertise reviewing radiology (imaging) studies in children with cancer, and a pathologist with expertise diagnosing childhood cancers
The primary care doctor (pediatrician)
Child life specialists, who work with children and families in hospitals and other settings to help them cope with the challenges of hospitalization, illness, and disability
A social worker, who can provide emotional support and help with financial aspects of care
A teacher, who can work with the child, the school, and the treatment team to make sure that the child’s education continues
A school liaison, who can also help the child and family interact with the teacher and school
A psychologist, who can help the child, siblings, and parents with their mental health throughout treatment
Many treatment teams also include a parent advocate. A parent advocate is another parent who had a child with cancer and who can offer guidance to families.
Children who are newly diagnosed with cancer should be evaluated by a cancer genetics team for genetic mutations that can predispose people to cancer or can have an impact on treatment.
More Information
The following English-language resources may be useful. Please note that THE MANUAL is not responsible for the content of these resources.
American Cancer Society: If Your Child Is Diagnosed With Cancer: A resource for parents and loved ones of a child who has cancer that provides information about how to cope with some of the problems and questions that come up just after a child is diagnosed
American Cancer Society: Cancer Facts & Figures 2024: A resource providing details about specific types of cancers, including numbers of new cancer cases and deaths, survival statistics, and information about symptoms
