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Common Side Effects of Injectable Antihyperglycemic Medications*

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Medication	Some Potential Side Effects
Glucagon-like peptide medication	All glucagon-like peptide medications can cause Nausea Vomiting Diarrhea or constipation They may also increase the risk of inflammation of the pancreas (pancreatitis) and some types of thyroid cancer
Albiglutide	—
Dulaglutide	—
Exenatide	Kidney damage (rare)
Extended-release exenatide	Injection site nodule
Liraglutide	—
Lixisenatide	—
Semaglutide†	May worsen eye damage from diabetes (diabetic retinopathy)
Dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist
Tirzepatide	Diarrhea Nausea or decreased appetite
Amylin-like medication
Pramlintide	Nausea Low blood glucose levels
* Insulin is the most commonly used injectable antihyperglycemic medication.
† Semaglutide is also available as a tablet to take orally.