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Common Side Effects of Injectable Antihyperglycemic Medications*

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Medication	Some Potential Side Effects
Glucagon-like peptide medication	All glucagon-like peptide medications can cause Nausea Vomiting Diarrhea or constipation They may also increase the risk of inflammation of the pancreas (pancreatitis) and some types of thyroid cancer
AlbiglutideAlbiglutide	—
DulaglutideDulaglutide	—
Exenatide Exenatide	Kidney damage (rare)
Extended-release exenatideExtended-release exenatide	Injection site nodule
LiraglutideLiraglutide	—
LixisenatideLixisenatide	—
Semaglutide†Semaglutide†	May worsen eye damage from diabetes (diabetic retinopathy)
Dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist
TirzepatideTirzepatide	Diarrhea Nausea or decreased appetite
Amylin-like medication
PramlintidePramlintide	Nausea Low blood glucose levels
* InsulinInsulin is the most commonly used injectable antihyperglycemic medication.
† Semaglutide is also available as a tablet to take orally.† Semaglutide is also available as a tablet to take orally.