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Some Medications and Substances That Can Damage the Liver

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Type of Drug	Examples
Antibiotics	Amoxicillin/clavulanate Amoxicillin/clavulanate ClindamycinClindamycin Erythromycin Erythromycin NitrofurantoinNitrofurantoin RifampinRifampin Sulfonamides Tetracyclines Trimethoprim/sulfamethoxazole Trimethoprim/sulfamethoxazole Medications used to treat tuberculosis (isoniazid and pyrazinamide)Medications used to treat tuberculosis (isoniazid and pyrazinamide)
Anticonvulsants	CarbamazepineCarbamazepine PhenobarbitalPhenobarbital PhenytoinPhenytoin Valproate
Antidepressants	BupropionBupropion FluoxetineFluoxetine MirtazapineMirtazapine ParoxetineParoxetine SertralineSertraline TrazodoneTrazodone Tricyclic antidepressants such as amitriptylineTricyclic antidepressants such as amitriptyline
Antifungals	KetoconazoleKetoconazole TerbinafineTerbinafine
Antihypertensives (used to treat high blood pressure or sometimes kidney or heart disorders)	CaptoprilCaptopril EnalaprilEnalapril IrbesartanIrbesartan LisinoprilLisinopril LosartanLosartan VerapamilVerapamil
Antipsychotics	Phenothiazines such as chlorpromazinePhenothiazines such as chlorpromazine RisperidoneRisperidone
Heart medications	AmiodaroneAmiodarone ClopidogrelClopidogrel
Hormones and related medications	Anabolic steroids Birth control pills (oral contraceptives) Estrogens
Pain relievers	AcetaminophenAcetaminophen NSAIDs
Other medications	Acarbose (used to treat diabetes)Acarbose (used to treat diabetes) Allopurinol (used to treat gout)Allopurinol (used to treat gout) Antiretroviral drugs (used to treat HIV infection) Baclofen (a muscle relaxant)Baclofen (a muscle relaxant) Cyproheptadine (an antihistamine)Cyproheptadine (an antihistamine) Azathioprine (used to prevent rejection of an organ transplant)Azathioprine (used to prevent rejection of an organ transplant) Methotrexate (used to treat cancer)Methotrexate (used to treat cancer) Omeprazole (used to treat gastroesophageal reflux)Omeprazole (used to treat gastroesophageal reflux) PD-1/PD-L1 inhibitors (anticancer drugs) Statins (used to treat high cholesterol levels) Many types of chemotherapy, including immune checkpoint inhibitors
Medicinal herbs	Germander Green tea extractGreen tea extract Kava Some energy drinks
NSAID = nonsteroidal anti-inflammatory drug.