When Generic Substitution May Not Be Appropriate
Drug Category | Examples | Comments |
|---|---|---|
Antiasthmatic drugs taken by mouth | Different versions are generally not bioequivalent. If one version is working, it should not be interchanged for another unless absolutely necessary. | |
Anticoagulants | Toxic dose for the drug is too close to the effective dose for the drug to be used safely. | |
Antidepressants | Not all versions are interchangeable. A pharmacist can advise whether the FDA considers a particular generic drug bioequivalent to the brand-name drug. | |
Antiseizure drugs | Loss of seizure control has occurred after people switch brands. Continuity of the same brand, or the same generic preparation, is recommended. | |
Antihypertensive drugs | Some generic versions are not bioequivalent to brand-name drugs. Modified-release preparations have different release characteristics and are not interchangeable. | |
Cardiovascular drugs | Toxic dose is too close to the effective dose for the drug to be used safely. | |
Corticosteroid creams, lotions, and ointments | These products are standardized by tests of skin response, and many have been rated as bioequivalent by the FDA. But response varies, and different drug vehicles (creams, ointments, gels) can affect product potency. Response may be unpredictable. So, if one version is effective, it should not be interchanged for another. | |
Corticosteroid tablets | Generic versions may not be bioequivalent to brand-name drugs and should not be freely interchanged for them. | |
Gout-control drugs | Generic versions of individual drugs are not bioequivalent to one another. | |
Hormones | Thyroid-replacement products | Hormones are usually taken in small doses, so differences in brands could produce major swings in response. Some brands are not bioequivalent. |
Psychiatric drugs | Toxic dose for the drug is too close to the effective dose for the drug to be used safely. | |
Other drugs | Generic versions may not be bioequivalent. Although any version can be effective, versions should not be interchanged. | |
* A generic drug is not available. † Modified-release preparations of drugs are versions of the drug in which the preparation has been changed in some way, usually to slow the release of the active ingredient into the bloodstream. Modified-release drugs may be identified by the designations MR, LA (long-acting), XL (extra long), CR (controlled release), or SR (sustained release). | ||
FDA = Food and Drug Administration. | ||