What is mastocytosis?
Mast cells are a part of your immune system involved in allergic reactions. Mastocytosis is a buildup of mast cells in your skin and sometimes other parts of your body.
Mastocytosis is rare
Symptoms include itchy spots and bumps, flushing, an upset stomach, and sometimes bone pain
Mastocytosis can affect just your skin or other parts of your body, such as your lungs and lining of your intestines
Mastocytosis of the skin alone isn't life-threatening and sometimes goes away without treatment
What causes mastocytosis?
Mastocytosis develops when your body makes too many mast cells. The mast cells can collect in your skin, bones, or other organs.
Mast cells produce a chemical called histamine. Too much histamine can cause:
Itching
Rash
Too much stomach acid
Low blood pressure
Doctors don’t always know why your body makes too many mast cells, but some people have a genetic mutation that causes mastocytosis.
What can trigger an attack of mastocytosis?
If you have mastocytosis, certain things can trigger an attack of symptoms, including:
Physical touch
Exercise
Things you eat or drink, such as foods, alcohol, and certain medicines
Insect stings
What are the symptoms of mastocytosis?
Symptoms include:
Small reddish brown spots or bumps that may itch
Flushing (turning red all over)
Stomach pain
Feeling sick to your stomach or throwing up
Diarrhea
Fainting and severe drops in blood pressure, which can be deadly
This photo shows reddish-brown spots on the back of a school-aged child with mastocytosis.
© Springer Science+Business Media
If mast cells build up in your tissues or organs, they can cause damage that can be life-threatening.
How do doctors tell if I have mastocytosis?
Doctors suspect mastocytosis from your symptoms, especially if you have itchy spots and get hives (red, itchy, raised patches on the skin) when you scratch. To know for sure, doctors will do tests, such as:
Biopsy (taking a small sample of skin to look at under a microscope)
Blood and urine tests
Sometimes, bone scan and genetic tests
How do doctors treat mastocytosis?
If you have mastocytosis only in your skin, doctors will treat itching and rashes with:
Antihistamines
Ultraviolet light
Corticosteroid creams
If mastocytosis affects other parts of your body, doctors will have you take medicine to help with your symptoms.
If your symptoms are severe, doctors may:
Give you a weekly shot to reduce the disease’s effects on your bones
Prescribe corticosteroids
Do surgery to remove your spleen, if mast cells have built up in your spleen