Comparison of Pharmacokinetic Outcomes for Diazepam in a Younger Man (A) and an Older Man (B)
Diazepam is metabolized in the liver to desmethyldiazepam through P-450 enzymes. Desmethyldiazepam is an active sedative, which is excreted by the kidneys. 0 = time of dosing. (Adapted from Greenblatt DJ, Allen MD, Harmatz JS, Shader RI: Diazepam disposition determinants. Clin Pharmacol Ther 27:301–312, 1980. doi: 10.1038/clpt.1980.40)
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