Abnormalities in Patients With Hypereosinophilic Syndrome
System | Prevalence | Manifestations |
|---|---|---|
Constitutional | ≈ 50% | Anorexia Fatigue Fever Myalgias Weakness Weight loss |
Cardiopulmonary | > 70% | Mural thrombi with emboli Restrictive or infiltrative cardiomyopathy or mitral or tricuspid regurgitation with cough, dyspnea, heart failure, arrhythmias, endomyocardial disease, pulmonary infiltrates, and pleural effusions |
Dermatologic | > 50% | Angioedema Dermatographism Pruritus Rashes (including eczema and urticaria) |
Hematologic | > 50% | Anemia Lymphadenopathy Splenomegaly Thromboembolic phenomena Thrombocytopenia |
Neurologic | > 50% | Cerebral emboli with focal deficits Diffuse encephalopathy with altered behavior and cognitive function and spasticity Peripheral neuropathy |
Gastrointestinal (GI) | > 40% | Abdominal cramps Diarrhea Nausea |
Immunologic | ≈ 40% | Circulating immune complexes with serum sickness Elevated levels of immunoglobulins (especially IgE) |