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Causes of Chronic Pancreatitis

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Causes	Examples
Toxins	Alcohol
Genetic	Cationic trypsinogen gene (PRSSI) Serine peptidase inhibitor Kazal-type 1 (SPINK1) Cystic fibrosis transmembrane conductance regulator gene (CFTR) Chymotrypsin C mutations and other genetic disorders
Obstructive	Pancreatic duct stricture (traumatic, iatrogenic, anastomotic, or malignant) Mass effect due to a tumor Possibly pancreas divisum (congenital anomaly causing division of the pancreatic duct) Possibly sphincter of Oddi dysfunction
Autoimmune	Type 1, related to IgG4 disease, and type 2 autoimmune pancreatitis
Idiopathic	Tropical pancreatitis
Other	Cigarette smoking