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Mechanism	Cause
Inadequate gastric mixing, rapid emptying, or both	Billroth II gastrectomy Gastrocolic fistula Gastroenterostomy
Insufficient digestive agents	Autoimmune metaplastic atrophic gastritis Biliary obstruction and cholestasis Cirrhosis Chronic pancreatitis Cholestyramine-induced bile acid loss Cystic fibrosis Lactase deficiency Pancreatic cancer Pancreatic resection Sucrase-isomaltase deficiency
Abnormal milieu	Abnormal motility secondary to diabetes, systemic sclerosis, hypothyroidism, or hyperthyroidism Small intestinal bacterial overgrowth (eg, due to blind loops, diverticula in the small intestine) Zollinger-Ellison syndrome (low duodenal pH)
Acutely abnormal epithelium	Acute intestinal infections Alcohol Neomycin
Chronically abnormal epithelium	Amyloidosis Celiac disease Crohn disease Ischemia Radiation enteritis Tropical sprue Whipple disease
Short bowel	Intestinal resection (eg, for Crohn disease, volvulus, intussusception, or infarction) Jejunoileal bypass for obesity
Impaired transport	Abetalipoproteinemia Addison disease Blocked lacteals due to lymphoma or tuberculosis Intrinsic factor deficiency (as in pernicious anemia) Lymphangiectasia