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Medication	Route
First generation
Cefadroxil	Oral
Cefazolin	Parenteral
Cephalexin	Oral
Cephradine	Oral
Second generation
Cefaclor	Oral
Cefotetan*	Parenteral
Cefoxitin*	Parenteral
Cefprozil	Oral
Cefuroxime	Parenteral or oral
Third generation
Cefdinir	Oral
Cefditoren	Oral
Cefixime	Oral
Cefoperazone/sulbactam (not available in the United States)	Parenteral
Cefotaxime	Parenteral
Cefpodoxime	Oral
Ceftazidime	Parenteral
Ceftazidime/avibactam	Parenteral
Ceftibuten	Oral
Ceftriaxone	Parenteral
Fourth generation
Cefepime	Parenteral
Anti-MRSA cephalosporins
Ceftaroline/fosamil	Parenteral
Ceftobiprole/medocaril	Parenteral
Other cephalosporins
Cefiderocol	Parenteral
Ceftolozane/tazobactam	Parenteral
* Also classified as a cephamycin.
MRSA = methicillin-resistant Staphylococcus aureus.