Clinical Staging of Chronic Lymphocytic Leukemia*

Rai

Stage 0

Absolute lymphocytosis of > 10,000/mcL (> 10 × 10⁹/L) in blood and ≥ 30% lymphocytes in bone marrow

Stage I

Stage 0 plus enlarged lymph nodes

Stage II

Stage 0 plus hepatomegaly or splenomegaly

Stage III

Stage 0 plus anemia with hemoglobin < 11 g/dL (< 110 g/L)

Stage IV

Stage 0 plus thrombocytopenia with platelet counts <100,000/mcL (< 100 × 10⁹/L)

Binet

Stage A

Absolute lymphocytosis of > 10,000/mcL (> 10 × 10⁹/L) in blood and ≥ 30% lymphocytes in bone marrow

Hemoglobin ≥ 10 g/dL ( ≥ 100 g/L)

Platelets ≥100,000/mcL (≥ 100 × 10⁹/L)

≤ 2 involved sites*

Stage B

As for stage A, but 3–5 involved sites

Stage C

As for stage A or B, but hemoglobin < 10 g/dL (< 100 g/L) or platelets < 100,000/mcL (100 × 10⁹/L)