Common Substances That Interact With Cytochrome P-450 Enzymes
Enzyme | Substrates | Inhibitors | Inducers |
|---|---|---|---|
CYP1A2 | AcetaminophenAcetaminophen Caffeine ClarithromycinClarithromycin EstradiolEstradiol HaloperidolHaloperidol LidocaineLidocaine MethadoneMethadone OlanzapineOlanzapine PropranololPropranolol RitonavirRitonavir Tacrine TheophyllineTheophylline Tricyclic antidepressants VerapamilVerapamil (R)-Warfarin-Warfarin | AmiodaroneAmiodarone CimetidineCimetidine CiprofloxacinCiprofloxacin ErythromycinErythromycin FluvoxamineFluvoxamine Ticlopidine | Charcoal-broiled beef Cigarette smoke OmeprazoleOmeprazole PhenobarbitalPhenobarbital PhenytoinPhenytoin RifampinRifampin |
CYP2C9 | CelecoxibCelecoxib DiclofenacDiclofenac FluoxetineFluoxetine GlipizideGlipizide GlyburideGlyburide IndomethacinIndomethacin NifedipineNifedipine PhenytoinPhenytoin PiroxicamPiroxicam ProgesteroneProgesterone TestosteroneTestosterone Tricyclic antidepressants Valproic acidValproic acid VoriconazoleVoriconazole (S)-Warfarin-Warfarin | AmiodaroneAmiodarone CimetidineCimetidine FluconazoleFluconazole Lovastatin Lovastatin RitonavirRitonavir SertralineSertraline Sulfamethoxazole TopiramateTopiramate TrimethoprimTrimethoprim VoriconazoleVoriconazole ZafirlukastZafirlukast | DexamethasoneDexamethasone PhenobarbitalPhenobarbital Other barbiturates PhenytoinPhenytoin RifampinRifampin |
CYP2C19 | DiazepamDiazepam (S)-Mephenytoin OmeprazoleOmeprazole PentamidinePentamidine PropranololPropranolol VoriconazoleVoriconazole (R)-Warfarin-Warfarin | CimetidineCimetidine FluoxetineFluoxetine FluvoxamineFluvoxamine KetoconazoleKetoconazole LansoprazoleLansoprazole OmeprazoleOmeprazole ParoxetineParoxetine Ticlopidine | CarbamazepineCarbamazepine Phenobarbital Phenobarbital PrednisonePrednisone RifampinRifampin |
CYP2D6 | Beta blockers CodeineCodeine DextromethorphanDextromethorphan FlecainideFlecainide HaloperidolHaloperidol LidocaineLidocaine MexiletineMexiletine MorphineMorphine OmeprazoleOmeprazole Phenothiazines QuinidineQuinidine RisperidoneRisperidone Selective serotonin reuptake inhibitors TamoxifenTamoxifen TestosteroneTestosterone TramadolTramadol TrazodoneTrazodone Tricyclic antidepressants VenlafaxineVenlafaxine | AmiodaroneAmiodarone BupropionBupropion CelecoxibCelecoxib CimetidineCimetidine FluoxetineFluoxetine FluvoxamineFluvoxamine MetoclopramideMetoclopramide MethadoneMethadone Paroxetine Paroxetine QuinidineQuinidine RitonavirRitonavir SertralineSertraline | CarbamazepineCarbamazepine DexamethasoneDexamethasone PhenobarbitalPhenobarbital PhenytoinPhenytoin RifampinRifampin |
CYP2E1 | AcetaminophenAcetaminophen Alcohol | DisulfiramDisulfiram | Alcohol IsoniazidIsoniazid Tobacco use |
CYP3A4 | AmiodaroneAmiodarone AprepitantAprepitant Azole antifungals Benzodiazepines Calcium channel blockers Caffeine CarbamazepineCarbamazepine ClarithromycinClarithromycin CyclosporineCyclosporine Delavirdine EnalaprilEnalapril EstradiolEstradiol Estrogen ErythromycinErythromycin FentanylFentanyl FinasterideFinasteride IndinavirIndinavir LidocaineLidocaine Lopinavir LoratadineLoratadine MethadoneMethadone NelfinavirNelfinavir OmeprazoleOmeprazole Opioid analgesics PrednisonePrednisone ProgesteroneProgesterone RitonavirRitonavir SaquinavirSaquinavir SildenafilSildenafil SirolimusSirolimus Statins TacrolimusTacrolimus TamoxifenTamoxifen Tricyclic antidepressants (R)-Warfarin-Warfarin | AmiodaroneAmiodarone Amprenavir AtazanavirAtazanavir Azole antifungals CimetidineCimetidine CiprofloxacinCiprofloxacin ClarithromycinClarithromycin Delavirdine DiltiazemDiltiazem ErythromycinErythromycin FluoxetineFluoxetine FluvoxamineFluvoxamine Grapefruit juice IndinavirIndinavir MetronidazoleMetronidazole NefazodoneNefazodone NelfinavirNelfinavir NifedipineNifedipine OmeprazoleOmeprazole ParoxetineParoxetine PosaconazolePosaconazole Propoxyphene RitonavirRitonavir SaquinavirSaquinavir SertralineSertraline VerapamilVerapamil VoriconazoleVoriconazole | CarbamazepineCarbamazepine DexamethasoneDexamethasone IsoniazidIsoniazid PhenobarbitalPhenobarbital PhenytoinPhenytoin PrednisonePrednisone RifampinRifampin |