Common Substances That Interact With Cytochrome P-450 Enzymes 

Enzyme

Substrates

Inhibitors

Inducers

CYP1A2

Caffeine

Tacrine

Tricyclic antidepressants

(R)

Ticlopidine

Charcoal-broiled beef

Cigarette smoke

CYP2C9

Tricyclic antidepressants

(S)

Sulfamethoxazole

Other barbiturates

CYP2C19

(S)-Mephenytoin

(R)

Ticlopidine

CYP2D6

Beta blockers

Phenothiazines

Selective serotonin reuptake inhibitors

Tricyclic antidepressants

CYP2E1

Alcohol

Alcohol

Tobacco use

CYP3A4

Azole antifungals

Benzodiazepines

Calcium channel blockers

Caffeine

Estrogen

Lopinavir

Opioid analgesics

Statins

Tricyclic antidepressants

(R)

Amprenavir

Azole antifungals

Grapefruit juice

Propoxyphene

In these topics