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Criteria	Specifics
ECG criteria*	ST-segment elevation in ≥ 2 contiguous leads
	Typical symptoms and left bundle branch block not known to be old
	Strictly posterior MI (large R wave in V1 and ST depression in V1–V4
Absolute contraindications	Aortic dissection
	Previous hemorrhagic stroke (at any time)
	Previous ischemic stroke within 1 year
	Active internal bleeding (not menses)
	Intracranial tumor
	Pericarditis
Relative contraindications	Blood pressure > 180/110 mm Hg after initial antihypertensive therapy
	Trauma or major surgery within 4 weeks
	Active peptic ulcer
	Pregnancy
	Bleeding diathesis
	Noncompressible vascular puncture
	Current anticoagulation (INR > 2)
* Patients presenting in the hyperacute phase of MI with giant T waves do not meet current criteria for fibrinolytics; ECG is repeated in 20 to 30 minutes to see if ST-segment elevation has developed.