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Histopathologic Subtypes of Hodgkin Lymphoma (WHO Classification)

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Histologic Type	Morphologic Appearance	Tumor Cell Immunophenotype
Classic
Nodular sclerosis	Dense fibrous tissue surrounding nodules of Hodgkin tissue	CD15+, CD30+, CD20–
Mixed cellularity	A moderate number of Reed-Sternberg cells with a mixed background infiltrate	CD15+, CD30+, CD20–
Lymphocyte-rich	Few Reed-Sternberg cells Many B cells	CD15+, CD30+, CD20–
Lymphocyte-depleted	Numerous Reed-Sternberg cells Extensive fibrosis	CD15+, CD30+, CD20–
Nodular lymphocyte-predominant*
	Few neoplastic cells (lymphocytic or histiocytic cells or both) Many small B cells Nodular pattern	CD15–, CD30–, CD20+, EMA+
EMA = epithelial membrane antigen.
* Nodular lymphocyte-predominant Hodgkin lymphoma has been reclassified as an non-Hodgkin B-cell lymphoma by the International Consensus Classification and is called nodular lymphocyte predominant B-cell lymphoma (see Campo E, Jaffe ES, Cook JR, et al. The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee [published correction appears in Blood 2023 Jan 26;141(4):437]. Blood 2022;140(11):1229-1253. doi:10.1182/blood.2022015851).