Immune Globulins and Antitoxins* Available in the United States
Immunobiologic Agent | Type | Indications |
|---|---|---|
Botulinum antitoxin | Specific equine antibodies | Treatment of botulism |
Botulinum antitoxin (BIG) | Specific human antibodies | Treatment of botulism in infants |
Specific human antibodies | Prophylaxis in hematopoietic stem cell transplant and kidney transplant recipients | |
Diphtheria antitoxin | Specific equine antibodies | Treatment of respiratory diphtheria |
Specific human antibodies | Prophylaxis for hepatitis B postexposure | |
Immune globulin (IG) | Pooled human antibodies | Prophylaxis for hepatitis A preexposure and postexposure, measles postexposure, immunoglobulin deficiency, rubella during the 1st trimester of pregnancy, varicella (if varicella zoster immune globulin is unavailable) |
Immune globulin, intravenous (IVIG) | Pooled human antibodies | Prophylaxis for and treatment of severe bacterial and viral infections (eg, HIV infection in children), primary immunodeficiency disorders, autoimmune thrombocytopenic purpura, chronic B-cell lymphocytic leukemia, Kawasaki disease, autoimmune disorders (eg, myasthenia gravis, Guillain-Barré syndrome, polymyositis/dermatomyositis) Prophylaxis for graft-vs-host disease |
Immune globulin, subcutaneous (SCIG) | Pooled human antibodies | Treatment of primary immunodeficiency disorders |
Specific human antibodies | Management of rabies postexposure | |
Respiratory syncytial virus (RSV) human monoclonal antibody | Prevention of RSV in infants born to mothers not adequately immunized against RSV | |
Specific human antibodies | Treatment of tetanus Postexposure prophylaxis in people not adequately immunized with tetanus toxoid | |
Specific human antibodies | Treatment of eczema vaccinatum, vaccinia necrosum, and ocular vaccinia | |
Specific human antibodies | Postexposure prophylaxis in people who have no evidence of immunity, are at increased risk of severe varicella, and have contraindications to the varicella vaccine | |
* Immune globulin preparations and antitoxins are given intramuscularly unless otherwise indicated. | ||
† Rabies immune globulin (HRIG) is given around wounds as well as intramuscularly. | ||
Adapted from Kroger A, Bahta L, Long S, et al: General best practice guidelines for immunization: Best practice guidance of the Advisory Committee on Immunization Practices (ACIP). Accessed on March 27, 2024. | ||