Options for Treatment of Superficial Fungal Infections*

Medications

Formulations

Uses†

Allylamines

Amorolfine‡

5% solution

Tinea unguium

1% cream or gel

Dermatophytoses, skin candidiasis

Topical: 1% cream or solution

Dermatophytoses

Oral: 250-mg tablet

Benzylamine

1% cream

Dermatophytoses

Imidazoles

2% cream

Vulvovaginal candidiasis

Topical: 1% cream, lotion, or solution; 100-, 200-, and 500-mg vaginal suppository tablets

Dermatophytoses, candidiasis (oropharyngeal, skin, vulvovaginal)

Oral: 10-mg lozenges

1% cream

Dermatophytoses, skin candidiasis, tinea versicolor

50 and 200 mg/5 mL solution; 50-, 100-, 150-, and 200-mg tablets

Candidiasis (vulvovaginal, skin, oropharyngeal)

100-mg capsules, 10 mg/mL solution

Tinea unguium, other onychomycoses

2% cream, 1 to 2% shampoo

Dermatophytoses, skin candidiasis

1 to 2% liquid (aerosol), 2% powder (aerosol), 1 to 2% cream and lotion, 1% solution, 2% powder or tincture, 100- or 200-mg vaginal suppositories

Dermatophytoses, candidiasis (skin, vulvovaginal)

1% cream or lotion

Dermatophytoses, tinea versicolor

1% cream or solution

Dermatophytoses, tinea versicolor

0.4% and 0.8% cream, 80-mg suppositories

Vulvovaginal candidiasis

6.5% ointment

Vulvovaginal candidiasis

Polyene

Topical: 100,000 units/g cream, ointment, powder, or vaginal tablet

Candidiasis (oropharyngeal, skin)

Oral: 100,000 units/mL suspension, 500,000-unit tablets

Candidiasis (oropharyngeal, gastrointestinal)

Miscellaneous

Carbolfuchsin

Solution

Chronic dermatophytoses, intertrigo

0.77% gel, 8% lacquer solution

Dermatophytoses, candidiasis, tinea versicolor, onychomycosis

Clioquinol¶

3% cream

Dermatophytoses

1 or 2% solution

Dermatophytoses, especially tinea pedis; sometimes candidiasis

125-, 165-, 250-, 330-, and 500-mg tablets

Dermatophytoses

1% liquid, powder, liquid or aerosol spray, cream, or solution

Dermatophytoses, tinea versicolor

Zinc

25% solution, 10% tincture

Superficial dermatophyte infections (eg, tinea pedis)

* Advantages of one topical medication over another for most infections are not clear. For skin infections, allylamines have good activity against dermatophytes but weaker activity against Candida; imidazoles have better activity against both dermatophytes and Candida. Adverse effects are rare, but all topical antifungals can cause skin irritation, burning, and contact dermatitis. Doses may vary by indication.

> 1 month.

† Fungal pathogens include yeast (eg, Candida) and dermatophytes.

‡ This medication is not available in the United States or Canada but is available elsewhere.

¶ This medication is not available in the United States.