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Oral Thiazide Diuretics for Hypertension in Children

Medication

Some Adverse Effects

Comments

ChlorthalidoneChlorthalidone

Common adverse effects: Dizziness, hypokalemia, increased blood glucose, alkalosis

Severe adverse effects: Cardiac dysrhythmias, cholestatic jaundice, pancreatitis

Contraindications include end stage renal disease and anuria.

Because chlorthalidone has a longer duration of action, it may be best for chronic hypertension where a single daily dose may help with adherence. Because chlorthalidone has a longer duration of action, it may be best for chronic hypertension where a single daily dose may help with adherence.

Chlorothiazide and hydrochlorothiazide should typically be given twice a day because of their shorter duration of action.Chlorothiazide and hydrochlorothiazide should typically be given twice a day because of their shorter duration of action.

ChlorothiazideChlorothiazide

HydrochlorothiazideHydrochlorothiazide