Pancreatic Endocrine Tumors
Tumor | Hormone | Tumor Location | Symptoms and Signs |
|---|---|---|---|
ACTHoma | ACTH | Pancreas | |
Gastrin | Duodenum (60%) Pancreas (30%) Other (10%) | Abdominal pain, peptic ulcer, diarrhea | |
Glucagon | Pancreas | Glucose intolerance, rash, weight loss, anemia | |
GRFoma | Growth hormone–releasing factor | Lungs (54%) Pancreas (30%) Jejunum (7%) Other (13%) | |
Insulin | Pancreas | Fasting hypoglycemia | |
Somatostatinoma | Somatostatin | Pancreas (56%) Duodenum/jejunum (44%) | Glucose intolerance, diarrhea, gallstones |
Vasoactive intestinal peptidase | Pancreas (90%) Other (10%) | Severe watery diarrhea, hypokalemia, flushing | |
ACTH = adrenocorticotropic hormone. | |||
Data from Tong Gan, B. Mark Evers, Small Intestine. In Sabiston Textbook of Surgery, 21st edition. Editors: Courtney Townsend, R. Daniel Beauchamp, B. Mark Evers, Kenneth Mattox, New York, Elsevier, 2021, pp.1276-1282. | |||