Postoperative Treatment of Ovarian Cancer by Stage and Type
Stage and Type | Treatment* |
|---|---|
Stage IA or B/grade 1 epithelial adenocarcinoma | No postoperative therapy |
Stage IA or B/grade 2 or 3 cancers Stage II cancer | 6 courses of chemotherapy (typically, paclitaxel and carboplatin)6 courses of chemotherapy (typically, paclitaxel and carboplatin) |
Stage III cancer | 6 courses of chemotherapy† as for stage IA or B/grade 2 or 3 Consideration of intraperitoneal cisplatin and paclitaxelConsideration of intraperitoneal cisplatin and paclitaxel |
Stage IV cancer | Infrequently, radiation therapy |
Germ cell tumors Stage II or III stromal tumors | Most often, combination chemotherapy, usually bleomycin, cisplatin, and etoposideMost often, combination chemotherapy, usually bleomycin, cisplatin, and etoposide |
* Maintenance therapy with bevacizumab or a PARP inhibitor is given to some patients with * Maintenance therapy with bevacizumab or a PARP inhibitor is given to some patients withBRCA mutations or homologous recombination deficiency. | |
† Intraperitoneal chemotherapy with cisplatin plus paclitaxel results in longer survival than IV chemotherapy but may have a higher complication rate.† Intraperitoneal chemotherapy with cisplatin plus paclitaxel results in longer survival than IV chemotherapy but may have a higher complication rate. | |
PARP = polyadenosine diphosphate-ribose polymerase. | |