Results of Aggregation Tests in Inherited Platelet Function Disorders

Disorder

Collagen, Epinephrine, and Low-Dose ADP

High-Dose ADP

Ristocetin

Disorders of amplification of platelet activation

Impaired

Normal

Normal

Thrombasthenia (eg, loss of the glycoprotein IIb/IIIa receptor)

Absent

Absent

Normal or impaired

Disorders of platelet adhesion (eg, Bernard-Soulier syndrome, von Willebrand disease)

Normal

Normal

Impaired

ADP = adenosine diphosphate.