Some Causes of a Solitary Pulmonary Nodule

Cause

Examples

Malignant causes*

Primary lung cancer

Adenocarcinoma

Small cell carcinoma

Metastatic cancer

Breast cancer

Melanoma

Colon cancer

Head and neck cancer

Renal cancer

Testicular cancer

Sarcoma

Nonmalignant causes

Autoimmune disorders

Granulomatosis with polyangiitis

Rheumatoid nodules

Benign tumors

Fibroma

Hamartoma

Lipoma

Granulomatous infection

Atypical mycobacterial infection

Blastomycosis

Coccidioidomycosis

Cryptococcosis

Histoplasmosis

Tuberculosis (TB)

Infection

Ascariasis

Aspergillosis

Bacterial abscess

Dirofilariasis (dog heartworm infection)

Echinococcus cyst

Pneumocystis jirovecii infection

Pulmonary vascular abnormalities

Cavernous angioma

Hemangioma

Pulmonary arteriovenous malformation

Pulmonary telangiectasis

Other

Amyloidosis

Bronchogenic cyst

Hematoma

Intrapulmonary lymph node

Loculated fluid

Mucoid impaction

Rounded atelectasis

* The likelihood of a malignant cause increases with age.