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Some Causes of and Risk Factors for Stillbirth

Type

Examples

Maternal

Preeclampsia or eclampsia

Trauma

Acquired thrombotic disorders

Diabetes mellitus if uncontrolled

Thyroid disorders

Morbid obesity (body mass index [BMI] ≥ 40 kg/m2)

Substance misuse

Tobacco use

Sepsis

Black race

Age (adolescents or ≥ 35 years)

Placental

Placental abruption

Intraamniotic infection (chorioamnionitis)

Fetomaternal hemorrhage

Twin-twin transfusion

Umbilical cord accidents (eg, prolapse, knots)

Uteroplacental vascular insufficiency

Vasa previa

Fetal

Chromosomal abnormalities

Single-gene disorders

Major congenital malformations (particularly of the heart or brain)

Alloimmune thrombocytopenia

Fetal alloimmune or inherited anemia

Nonimmune hydrops fetalis

Multiple gestation

Infection

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