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Some Causes of Otorrhea

Cause

Suggestive Findings

Diagnostic Approach

Acute discharge*

Acute otitis media with perforated TM

Severe pain, with relief on appearance of purulent discharge

History and physical examination

Sometimes audiogram

Sometimes high-resolution temporal bone CT if a complication of acute otitis media (eg, subperiosteal abscess, new onset vertigo or dizziness, facial nerve weakness/paralysis) is suspected

Chronic otitis media with perforated TM

Otorrhea in patients with chronic perforation, sometimes with cholesteatoma

Can also manifest as chronic discharge

Sometimes history and physical examination alone

Sometimes high-resolution temporal bone CT

Sometimes audiogram

CSF leak caused by head trauma

Significant, clinically obvious head injury or recent surgery

Fluid ranges from crystal clear to pure blood

High-resolution CT of the brain and skull base

MRI

Otitis externa (infectious or allergic)

Infectious: Often after swimming, local trauma; marked pain, worse with ear traction

Often a history of chronic ear dermatitis with itching and skin changes

Allergic (contact dermatitis): Often after use of ear drops; more itching, erythema, less pain than with infectious

Typically involvement of earlobe, where drops trickled out of ear canal

Both: Canal very edematous, inflamed, with debris; normal TM

History and physical examination alone

Post-tympanostomy tube

After tympanostomy tube placement

May occur with water exposure

History and physical examination alone

Chronic discharge

Cancer of ear canal

Discharge often bloody, mild pain

Sometimes visible lesion in canal

Easy to confuse with otitis externa early on

Biopsy

CT

MRI in some cases

Cholesteatoma

History of TM perforation

Flaky squamous debris in ear canal (dead skin), retraction pocket in TM filled with keratin debris or dead skin

Sometimes polypoid mass or granulation tissue over the cholesteatoma

CT

Culture

Sometimes diffusion weighted MRI to assess extension into the mastoid or intracranial extension

Chronic purulent otitis media

Long history of ear infections or other ear disorders

Less pain than with external otitis

Canal macerated, granulation tissue

TM immobile, distorted, usually visible perforation

Sometimes history and physical examination alone

Usually culture

Foreign body

Usually in children

Drainage foul-smelling, purulent

Foreign body often visible on examination unless marked edema or drainage

History and physical examination alone

Mastoiditis

Often fever, history of untreated or unresolved otitis media

Redness, tenderness over mastoid

CT with contrast

Necrotizing otitis externa

Usually history of immune deficiency or diabetes

Chronic severe pain

Periauricular swelling and tenderness, granulation tissue in ear canal

Sometimes facial nerve paralysis or dysfunction of other cranial nerves (9, 10, 11, 12)

CT and MRI are complementary and are recommended

Sometimes radionuclide studies (eg,technetium-99 and gallium scans)

Culture

Granulomatosis with polyangiitis

Often with respiratory tract symptoms, chronic rhinorrhea, arthralgias, and oral ulcers

Urinalysis

Chest radiograph

Antineutrophilic cytoplasmic antibody testing

Biopsy

Nasolaryngoscopy to assess for other commonly affected sites (eg, septum, subglottis)

* < 6 weeks

CSF=cerebrospinal fluid; CT = computed tomography; MRI = magnetic resonance imaging; TM = tympanic membrane.

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