Some Differences Between Bartter Syndrome and Gitelman Syndrome
Feature | Bartter Syndrome | Gitelman Syndrome |
|---|---|---|
Location of kidney defect | Ascending loop of Henle (mimics effects of loop diuretics) | Distal tubule (mimics effects of thiazides) |
Urinary calcium excretion | Normal or increased, commonly with nephrocalcinosis | Decreased |
Serum magnesium level | Normal or decreased | Decreased, sometimes greatly |
Renal prostaglandin E2 production | Increased | Normal |
Usual age at presentation | Before birth to early childhood, often with intellectual disability and growth disturbance | Late childhood to adulthood |
Neuromuscular symptoms (eg, muscle spasms, weakness) | Uncommon or mild | Common |
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