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Some Medications That Cause Immunosuppression

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Class	Examples
Antiseizure medications	Lamotrigine Phenytoin Valproate
Biologics and small molecules	Interleukin (IL)-1 inhibitors (eg, anakinra) IL-6 inhibitors (eg, tocilizumab) IL-17 inhibitors (eg, brodalumab) Tumor necrosis factor (TNF) inhibitors (eg, adalimumab, etanercept, infliximab) T-cell activation inhibitors (eg, abatacept, basiliximab) CD20 inhibitors (eg, rituximab, ofatumumab) CD3 inhibitors (eg, muromonab-CD3) Complement inhibitors (eg, sutimlimab, pegcetacoplan, eculizumab, avacopan) Janus kinase (JAK) inhibitors (eg, ruxolitinib) Other B cell–targeting medications (eg, blinatumomab, belimumab, axicabtagene ciloleucel [CART-T therapy])
Calcineurin inhibitors	Cyclosporine Tacrolimus Voclosporin
Corticosteroids	Methylprednisolone Prednisone
Cytotoxic chemotherapy agents	Multiple (see Systemic Antineoplastic Therapy)
Immunosuppressive immunoglobulins	Antilymphocyte globulin Antithymocyte globulin
Purine metabolism inhibitors	Azathioprine Mycophenolate
Rapamycins	Everolimus Sirolimus