Some Oral Medications for Dyspepsia

Proton pump inhibitors

DexlansoprazoleDexlansoprazole

With long-term use, elevated gastrin levels, but no evidence that this finding causes dysplasia or cancer

May cause abdominal pain or diarrhea

EsomeprazoleEsomeprazole

LansoprazoleLansoprazole

OmeprazoleOmeprazole

PantoprazolePantoprazole

RabeprazoleRabeprazole

H2 blockers

CimetidineCimetidine

Doses reduced in older adults

With cimetidine and to a lesser extent with other medications, minor antiandrogen effects and, less commonly, erectile dysfunctionWith cimetidine and to a lesser extent with other medications, minor antiandrogen effects and, less commonly, erectile dysfunction

Delayed metabolism of medications eliminated by cytochrome P-450 enzyme system (eg, phenytoin, warfarin, diazepam)Delayed metabolism of medications eliminated by cytochrome P-450 enzyme system (eg, phenytoin, warfarin, diazepam)

May cause constipation or diarrhea

FamotidineFamotidine

NizatidineNizatidine

Ranitidine†Ranitidine†

Cytoprotective agent

SucralfateSucralfate

Rarely constipation

May bind to other medications and interfere with absorption

Cimetidine, ciprofloxacin, digoxin, norfloxacin, ofloxacin, and ranitidine† avoided 2 hours before or after taking sucralfateCimetidine, ciprofloxacin, digoxin, norfloxacin, ofloxacin, and ranitidine† avoided 2 hours before or after taking sucralfate